发明名称 |
2, 4-PENTADIENOIC ACID DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X (RXR) RECEPTORS |
摘要 |
<p>Compounds of Formula (1), Formula (2) or Formula (3) where X is O, S, or (CR1R1)n where n is 0, 1, or 2; Y is a bivalent radical having Formula (4) or Formula (5) where o is an integer from 1 to 4 or Y is a bivalent aryl or 5 or 6 membered heteroaryl radical having 1 to 3 heteroatoms selected from N, S and O, said aryl or heteroaryl groups being unsubstituted, or substituted with 1 to 3 C1-6 alkyl or with 1 to 3 C1-6 fluoroalkyl groups; and the remaining symbols have the meaning described in the specification, have RXR selective retinoid agonist-like activity.</p> |
申请公布号 |
WO0020370(A1) |
申请公布日期 |
2000.04.13 |
申请号 |
WO1999US21712 |
申请日期 |
1999.09.20 |
申请人 |
ALLERGAN SALES, INC. |
发明人 |
VULIGONDA, VIDYASAGAR;TSANG, KWOK, YIN;VASUDEVAN, JAYASREE;CHANDRARATNA, ROSHANTHA, A. |
分类号 |
A61K31/201;A61K31/231;A61K31/352;A61P1/00;A61P3/02;A61P3/06;A61P5/06;A61P9/00;A61P11/00;A61P17/00;A61P17/04;A61P17/06;A61P17/10;A61P17/14;A61P17/16;A61P25/16;A61P25/28;A61P27/02;A61P35/00;A61P37/02;A61P43/00;C07C57/48;C07C57/50;C07C69/00;C07C69/618;C07D311/58;(IPC1-7):C07C57/50;A61K31/192;A61K31/216 |
主分类号 |
A61K31/201 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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