发明名称 |
TRICYCLIC DELTA 3-PIPERIDINES AS PHARMACEUTICALS |
摘要 |
The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; n is 1 or 2; X is -O-, -S-, -S(=O)- or -S(=O)2-; each R<1> is independently hydrogen, halogen, C1-6alkyl, nitro, hydroxy or C1-4alkyloxy; D is an indole, a benzisoxazole, a benzisothiazole, a 2H-benzopyranone, a phenoxyphenyl, a benzamide, a benzophenone or a benzopyrimidinone having central alpha 2-adrenoceptor antagonist activity. It further relates to their preparation, pharmaceutical use and compositions.
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申请公布号 |
WO0020423(A1) |
申请公布日期 |
2000.04.13 |
申请号 |
WO1999EP07420 |
申请日期 |
1999.10.01 |
申请人 |
JANSSEN PHARMACEUTICA N.V.;KENNIS, LUDO, EDMOND, JOSEPHINE;MERTENS, JOSEPHUS, CAROLUS;BRAEKEN, MIRIELLE |
发明人 |
KENNIS, LUDO, EDMOND, JOSEPHINE;MERTENS, JOSEPHUS, CAROLUS;BRAEKEN, MIRIELLE |
分类号 |
A61K31/4353;A61K31/4355;A61K31/4365;A61P3/10;A61P15/10;A61P25/00;A61P25/16;A61P25/24;A61P25/28;A61P27/06;A61P43/00;C07D221/00;C07D307/00;C07D333/00;C07D491/04;C07D491/048;C07D495/04;(IPC1-7):C07D495/04;A61K31/435 |
主分类号 |
A61K31/4353 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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