| 摘要 |
In the present invention there are disclosed 1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-alkyl-3H-1,2,4-triazol-3-one heteroaryl substituted derivatives of the general formula I, in which A and B together represent a bivalent radical of the general formula -N=CH- (a), -CH=N- (b), -CHi2-CHi2- (c), -CH=CH- (d), -C(=O)-CHi2- (e) or -CHi2-C(=O)- (f), whereby in the bivalent radical of the formula (a) or (b) the hydrogen atom can be optionally substituted with an alkyl group containing 1 to 6 carbon atoms and in the bivalent radical of the formulas (c), (d), (e) or (f) one or two hydrogen atoms can be optionally substituted with alkyl groups containing 1 to 6 carbon atoms, Re1 represents a hydrogen atom, an alkyl group containing 1 to 6 carbon atoms or a halogen, Re2 represents a hydrogen atom or a halogen atom, Re3 represents a hydrogen atom, an alkyl group containing 1 to 8 carbon atoms, a cycloalkyl group containing 3 to 6 carbon atoms or an alkyl group containing 1 to 8 carbon atoms being substituted with hydroxyl, an oxo group a cycloalkyl containing 3 to 6 carbon atoms or an aryl group, Het represents a heterocyclic radical being defined in the Claims and the aryl group is represented by phenyl being optionally substituted with alkyl containing 1 to 6 carbon atoms or with a halogen, further their N-oxides, stereochemically isomeric forms and pharmaceutically acceptable acid addition salts, intermediates of the general formula III in which Re1, Re2 and Het are as specified above and W represents a leaving group such as halogen or sulfonyloxy and their acid addition salts or stereochemically isomeric forms, further process for preparing the compounds of the general formula I as well as pharmaceutical preparations based thereon. The compounds of the general formula are suitable for treating hyperlipemia.
|
