| 摘要 |
Apoptosis, the main mechanism of programmed cell death, is a gene directed process responsible for the elimination of excessive cells during development and detrimental cell types in pathophysiological situations. The present invention provides a method for exploiting the molecular mechanisms which regulate the pathways leading to programmed cell death, and tumor regression without significant side-effects to the patient. Both low dose chemotherapy and radiotherapy induce DNA fragmentation, but not necessarily cell death, thereby positioning tumor cells to self-destruct by apoptosis. By infusing low doses of cytokines to patients undergoing chemotherapy and/or radiotherapy, tumor cells containing damaged DNA are induced into apoptosis resulting in tumor regression without significant side-effects to the patient.
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