发明名称 |
Substituted benzoylpiperidine derivatives and their use as Neurokinin antagonists |
摘要 |
<p>The present invention provides a compound of the formula:- <CHEM> or a pharmaceutically acceptable acid addition salt thereof, wherein Ar is phenyl substituted by 1 or 2 substituent(s) each independently selected from fluoro and chloro; X is NSO2(C1-C4 alkyl), NSO2(halo(C1-C4 alkyl)) or O; m is 0 or 1 ; n is 1 or 2; p is 1 or 2; q is 1 or 2; and r is 1 or 2, together with processes for the preparation of, intermediates used in the preparation of, compositions containing and uses of, such derivatives. The compounds have tachykinin receptor antagonist activity.</p> |
申请公布号 |
EP0992493(A1) |
申请公布日期 |
2000.04.12 |
申请号 |
EP19990307878 |
申请日期 |
1999.10.06 |
申请人 |
PFIZER INC.;PFIZER LIMITED |
发明人 |
FOX, DAVID NATHAN ABRAHAM |
分类号 |
A61K31/4523;A61K31/4427;A61K31/443;A61K31/451;A61K31/453;A61K31/454;A61K31/4545;A61P1/00;A61P11/00;A61P13/00;A61P15/00;A61P17/00;A61P19/02;A61P25/00;A61P29/00;A61P37/08;A61P43/00;C07D211/96;C07D401/04;C07D401/14;C07D405/04;C07D405/14;(IPC1-7):C07D211/28;C07D405/06;A61K31/44;C07D403/14;C07D309/04 |
主分类号 |
A61K31/4523 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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