| 摘要 |
A compound of formula (I): wherein: X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description, Y represents oxygen, sulphur, NR3, or may a single bond when X represents NR3, Z represents nitrogen, carbon, or CH, A represents a single bond, alkylene (optionally substituted), arylene, cycloalkylene, heterocycle, or -SO2-R4- wherein R4 is as defined in the description, W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycle bonded to oxygen, amino, or hydroxyamino, Ra, Rb, Rc, Rd, which may be the same or different, each independently of the others are as defined in the description, R1 represents aryl substituted by one to five identical or different substituents, each independently of the others, R2 represents hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, heterocycle, heterocycloalkyl, or another group as defined in the description, isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in the treatment of thrombosis, pathologies for which the origin is thrombosis, or pathologies causing an increase in risk of thrombosis.
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