发明名称 |
Recombinant materials for producing humanized anti-IL-8 antibodies |
摘要 |
Monoclonal antibodies immunospecific for the neutrophil chemotactic factor, IL-8, have been humanized by reshaping the variable regions to conform more closely to human counterparts. These antibodies are useful in immunoassays to detect IL-8 and as ligands on immunoaffinity columns for purification of human IL-8. In addition, the humanized antibodies have an antiinflammatory effect in patients.
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申请公布号 |
US6048972(A) |
申请公布日期 |
2000.04.11 |
申请号 |
US19970880142 |
申请日期 |
1997.06.20 |
申请人 |
CHUGAI PHARMACEUTICAL CO., LTD. |
发明人 |
MATSUSHIMA, KOUJI;MATSUMOTO, YOSHIHIRO;YAMADA, YOSHIKI;SATO, KOH;TSUCHIYA, MASAYUKI;YAMAZAKI, TATSUMI |
分类号 |
A61K39/395;A61P29/00;A61P37/02;C07K16/24;C12N15/13;C12P21/08;(IPC1-7):C12N15/13;C12N5/10 |
主分类号 |
A61K39/395 |
代理机构 |
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