发明名称 |
Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
摘要 |
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are describer featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. The formulations described herein interact with free radicals, act as antioxidant enzyme-mimics, and alleviate oxidative stress and oxygen-related toxicity.
|
申请公布号 |
US6048967(A) |
申请公布日期 |
2000.04.11 |
申请号 |
US19980128375 |
申请日期 |
1998.08.03 |
申请人 |
SYNZYME TECHNOLOGIES, INC. |
发明人 |
HSIA, JEN-CHANG |
分类号 |
A61K9/127;A61K38/00;A61K38/16;A61K38/42;A61K45/06;A61K47/48;A61K49/00;A61K49/20;A61P7/08;C07K1/10;C07K14/76;C07K14/805;C07K16/00;(IPC1-7):C07K14/805 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|