发明名称 |
Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies |
摘要 |
An essentially pure immunogenic composite capable of selectively inducing antibody production in an animal to a peptide that if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate production of anti-peptide antibody in the animal. This immunogenic composite comprises: a lipid and an amphipathic peptide. The amphipathic peptide if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate production of anti-peptide antibody in the animal. The amphipathic peptide is covalently bound to the lipid in a peptide-lipid complex. The immunogenic composite has a vesicular or an amorphous particulate structure. Another embodiment of this immunogenic composite comprises: a lipid, the amphipathic peptide, and a hydrophilic peptide covalently bound together. The hydrophilic peptide if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate production of anti-peptide antibody in the animal.
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申请公布号 |
US6048531(A) |
申请公布日期 |
2000.04.11 |
申请号 |
US19930160093 |
申请日期 |
1993.12.01 |
申请人 |
ALBANY MEDICAL COLLEGE |
发明人 |
MANNINO, RAPHAEL JAMES;GOODMAN-SNITKOFF, GAIL |
分类号 |
A61K39/21;A61K39/385;A61K47/48;A61P37/04;(IPC1-7):A61K39/385;C07K17/06 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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