Chewable compositions containing dextromethorphan

摘要

Disclosed is a composition comprising dextromethorphan particles coated with a polymethacrylate copolymer, the coated particles having a particle size of less than about 150 microns. Further disclosed is a method for preparing a composition comprising dextromethorphan coated with a polymethacrylate copolymer, comprising the steps of: (a) dissolving dextromethorphan and polymethacrylate copolymer in a solvent, the ratio of the dextromethorphan to the polymethacrylate copolymer being from about 3:97 to about 50:50; (b) concentrating the dissolved solution obtained by step (a); (c) spraying the concentrated solution obtained by step (b) in a water bath maintained at from about 5 DEG C to about 85 DEG C and containing a dispersing agent to obtain a co-precipitate, the co-precipitate having a particle size of less than about 150 microns; (d) washing and drying the co-precipitate obtained by step (c). Still further disclosed are chewable tablets comprising such coated dextromethorphan compositions.