| 摘要 |
<p>A process for preparing a compound of the general formula (I) in which n is 1; Ar is, for example, a napthyl group, quinolyl group, isoquinolyl group and the like; and X and Y, together with the phenyl to which they are attached, form a ring system selected from a quinolyl group, benzothiazolyl group, indazolyl group and the like; and a pharmaceutically acceptable acid addition salt thereof, which process comprises reacting a piperazine of the formula (II) wherein Z is fluoro, chloro, bromo, iodo, methanesulfonate, trifluoromethanesulfonate, or trifluoroacetate; n' is 0 or 1; and Ar is as defined above, with an alkyl halide containing compound of the formula (III) wherein n, X and Y are as defined above and Hal is fluoro, chloro, bromo or iodo.</p> |
