RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF METABOLIC BONE DISORDERS

摘要

The object of the present invention are compounds of general formula (I), in which m signifies a number between 0 and 8; q signifies a number between 0 and 8; X signifies the group CH2 or C=S, whereby A signifies a single bond and m signifies 0 when X signifies CH2; A signifies a single or double bond; R1, R2 signify hydrogen or lower alkyl, whereby R1 and R2 can be the same or different and, when m signifies 2-8, R1 and R2 in the group CR1=CR2 can have various significances within the following sequence; R3 signifies hydrogen or lower alkyl; Z signifies oxygen, sulphur; W signifies an optionally mono- or polysubstituted saturated or unsaturated mono-, bi- or tricycle which can contain one or more hetero atoms, as well as their physiologically compatible salts, esters, optically active forms, racemates, tautomers, as well as derivatives which can be metabolized in vivo to compounds of general formula (I), as well as the use of these compounds for the production of medicaments for the prophylaxis or therapy of metabolic bone disorders.