OXAZOLE COMPOUNDS AS PROSTAGLANDIN E2 AGONISTS OR ANTAGONISTS

摘要

Oxazole compounds of formula (I), wherein R<1> is aryl which may be substituted with halogen(s), R<2> is aryl which may be substituted with halogen(s), X is single bond, (a) or SO2, R<3> and R<4> are independently hydrogen or suitable substituent, (wherein X is (a), neither R<3> nor R<4> is hydrogen), R<3> and R<4> may be linked together to form (b), (b) is N-containing heterocyclic group which may be substituted with one or more suitable substituent(s), R<5> is hydrogen, etc., A<1> is lower alkylene or single bond, (c) is cyclo(C3-C9)alkane or cyclo(C5-C9)alkene, or a pro-drug thereof, or a pharmaceutically acceptable salt thereof, which are useful as medicament.