NEW DERIVATIVES OF 6-(4-PHENYLBUTOXY)HEXYLAMINE AND PROCESS FOR PRODUCING SALMETEROL

摘要

The present invention relates to new derivatives of 6-(4-phenylbutoxy)hexylamine having the general formula (I) wherein R1 is CHO, or CHOR3OR4, wherein R3 and R4 are independently C1-C6 alkyl, aralkyl or can form cyclic acetals with 5 or 6 members; R2 is H, benzyl or a group alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or acyle; the invention also relates to the process for producing them. The invention also relates to a new process for producing salmeterol or the pharmaceutically acceptable salts thereof and which is characterized in that an organometallic compound is reacted with a compound having the general formula (I) wherein R1 is CHO and R2 is alkyloxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl or an acyl group.