BENZAMIDE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS

摘要

The invention concerns amide derivatives of formula (I) wherein R<3> is (1-6C)alkyl or halogeno; m is 0-3, p is 0-2 and q is 0-4; each of R<1> and R<2> is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R<4> is a basic group such as amino, (1-6C)alkylamino, di-[(1-6C)alkyl]amino, di-[(1-6C)alkyl]amino-(1-6C)alkyl, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, heteroaryl, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; and Q<2> is a group such as heteroaryl, heteroaryloxy or heteroaryl-(1-6C)alkoxy which is optionally substituted; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.