发明名称 |
Diffusion gradient bioreactor and extracorporeal liver device |
摘要 |
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood. |
申请公布号 |
AU718021(B2) |
申请公布日期 |
2000.04.06 |
申请号 |
AU19970028081 |
申请日期 |
1997.04.18 |
申请人 |
ADVANCED TISSUE SCIENCES, INC. |
发明人 |
BRIAN A. NAUGHTON;CRAIG R. HALBERSTADT;BENSON SIBANDA |
分类号 |
C12M1/00;A01N1/02;A61F2/02;A61M1/34;A61M1/36;C12M1/16;C12M3/06;C12N5/00;C12N5/071 |
主分类号 |
C12M1/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|