NOVEL ANTIBODIES, DRUGS CONTAINING THESE ANTIBODIES AND METHODS FOR SCREENING COMPOUNDS BY USING THESE ANTIBODIES

摘要

An antibody recognizing a novel transmembrane matrix metalloprotease polypeptide [MT4-MMP(2)] which has a physiological activity different from MT4-MMP reported hitherto; preventives, diagnostics and remedies for various diseases such as arthrosis deformans, rheumatoid arthritis, asthma, autoimmune diseases and atopic dermatitis which contain the above antibody; a method for screening an MT4-MMP(2) inhibitor or activator by using the above antibody, etc. An antibody recognizing a novel human and mouse transmembrane matrix metalloprotease polypeptide MT5-MMP which has a physiological activity; preventives, diagnostics and remedies for various diseases such as arthrosis deformans, rheumatoid arthritis, asthma, autoimmune diseases, atopic dermatitis, brain failure such as cerebral stroke, and Alzheimer's disease which contain the above antibody; a method for screening an MT5-MMP inhibitor or activator by using the above antibody, etc.