METHOD FOR CONTROLLING THE RELEASE OF GRANULES

摘要

A method for controlling the release of granules by treating a cell system capable of releasing granules so as to increase or decrease activated calgranulin to thereby enhance or depress the release of granules. A method for detecting a substance capable of activating or inhibiting the capability of releasing granules by using the above method. Activated calgranulin is increased by making the cells highly permeable and introducing calgranulin and soluble calcium thereinto. Activated calgranulin is decreased by introducing a calgranulin antibody into the cells. These methods are useful in screening a substance capable of activating or inhibiting the release of granules.