CHROMENE DERIVATIVE USEFUL FOR A CDK INHIBITOR

摘要

PURPOSE: A composition of anti-cancer medicine composition is provided to include a new chromene derivative as an active component, interfering CDK(Cyciln Dependent Kinase) activity. CONSTITUTION: A new chromene derivative of a chemical formula 1 is useful as an inhibitor of Cyciln Dependent Kinase. A composition of anti-cancer agent includes the composition and pharmaceutically acceptable salts, as an active component. In the chemical formula 1, R1 and R2 are substituted each other at locations of o,m or p, and represent hydrogen, hydroxy, chloro, or low alkoxy, respectively; R3 is hydrogen or hydroxy; and R4 and R5 are substituted each other at locations of the o,m or the p, and represent hydrogen, chloro, hydroxy, or low alkoxy respectively or the both represent low alkoxy.