| 摘要 |
<p>Human β-globin mutant polypeptides comprise the amino acid sequence of normal human β-globin modified by (i) the substitution or deletion of Cys at positions (93) and (112), and (ii) the substitution of a Cys for a non-Cys amino acid at one other position in the polypeptide, preferably Ser at position (9). Modified human hemoglobins containing this or other β-globin mutations, and/or an α-globin mutation, are provided, as well as polymers of such modified hemoglobins. Nucleic acids, vectors and transformed host cells for producing the β-globin mutants are provided.</p> |
