发明名称 |
REVERSIBLY IMMORTALIZED HEPATOCYTES AND METHODS OF USE |
摘要 |
Hepatocyte cells that are reversibly immortalized and grown in culture, which are functional and safe for use in transplantation, are disclosed. Also disclosed are methods for immortalizing primary hepatocytes, expanding the population of immortalized hepatocytes in culture, then reversing the immortalization to produce hepatocytes that are functional and safe for use in transplantation. |
申请公布号 |
WO0018239(A1) |
申请公布日期 |
2000.04.06 |
申请号 |
WO1999US22207 |
申请日期 |
1999.09.24 |
申请人 |
UNIVERSITY OF NEBRASKA BOARD OF REGENTS;HARVARD-MIT DIVISION OF HEALTH SCIENCE AND TECHNOLOGY;FOX, IRA, J.;LABOULCH, PHILLIPPE |
发明人 |
FOX, IRA, J.;LABOULCH, PHILLIPPE |
分类号 |
A61K35/12;C07K14/025;C12N5/071;C12N9/00;C12N9/12 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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