摘要 |
<p>The present invention provide the following Sulfonamide derivatives which have low toxicity and a potent effect of inhibiting tubulin polymerization. The pharmaceutical compositions containing the said compound as an active ingredient correct abnormalities in the immune system and are useful as preventives or remedies of rheumatism such as inflammatory rheumatism or as anticancer agents. That is, the present invention relates to Sulfonamide derivatives represented by the general formula(1) <CHEM> Äwherein preferably R<1> is a lower alkyl group, R<2> , R<3>, R<4>, R<5>, R<6> may be the same or different and each independently represents a hydrogen atom, a halogen atom, a nitro group, a lower alkyl group, an optionally substituted amino group or alkyl group. A represents any group of (1)an optionally substituted 5-membered heterocyclic group (except triazolyl group)whose ring members include at least 1 nitrogen atom and may include any atom(s) selected from the group consisting nitrogen atom, oxygen atom, and sulfur atom, (2)an optionally substituted alicyclic group, and (3)an alicyclic group whose ring members include at least 1 nitrogen atom and may include any atom(s) selected from the group consisting of nitrogen atom, oxygen atom, and sulfur atomÜ, and the pharmaceutically acceptable salts thereof and the use thereof as a pharmaceutical composition.</p> |