发明名称 AQUEOUS COATING AGENT AND PRODUCTION OF SOLID PHARMACEUTICAL FORMULATION
摘要 PROBLEM TO BE SOLVED: To obtain an aqueous coating agent capable of making the use of hydroxypropylmethyl cellulose trimellitate being a low pH dissolution base in an aqueous base by making the coating agent include hydroxypropylmethyl cellulose trimellitate and a plasticizer. SOLUTION: This coating agent comprises (A) hydroxypropylmethyl cellulose trimellitate having preferably <=10μm average particle diameter and (B) a plasticizer (e.g. triethyl citrate, triacetylene, acetylated monoglyceride, dimethyl phthalate, diethyl phthalate, etc.). The coating agent contains 3-15 wt.% of the component A. Preferably the amount of the component B added is 20-60 wt.% based on the component A. The coating agent is obtained by dispersing the pulverized component A into an aqueous solution containing the component B with ordinary stirring preferably at <=40 deg.C solution temperature.
申请公布号 JP2000095709(A) 申请公布日期 2000.04.04
申请号 JP19980288829 申请日期 1998.09.25
申请人 SHIN ETSU CHEM CO LTD 发明人 KOKUBO HIROYASU;NISHIYAMA YUICHI
分类号 A61K9/28;A61K9/36;A61K9/62;A61K47/38;(IPC1-7):A61K47/38 主分类号 A61K9/28
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