| 发明名称 |
Process for making morphine-6-glucuronide or substituted morphine-6-glucuronide |
| 摘要 |
Morphine-6-glucuronide or substituted morphine-6-glucuronide of formulae (I) is made by conjugation of a glucuronate ester and/or substituted glucuronate ester with morphine or substituted morphine in the presence of a Lewis acid catalyst and in the absence of silver catalysts and barium hydroxide and other heavy metal derivatives.
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| 申请公布号 |
US6046313(A) |
申请公布日期 |
2000.04.04 |
| 申请号 |
US19960688727 |
申请日期 |
1996.07.31 |
| 申请人 |
SALFORD ULTRAFINE CHEMICALS AND RESEARCH LIMITED |
发明人 |
SCHEINMANN, FEODOR;LUMBARD, KEITH WILLIAM;BROWN, RICHARD TALBOT;MAYALARP, STEPHEN PATRICK;CARTER, NEIL EDWARD |
| 分类号 |
A61K31/4355;A61K31/485;C07D489/00;C07D489/02;C07G3/00;C07H;C07H1/00;C07H13/02;C07H13/04;C07H17/00;C07H17/02;C07H19/00;(IPC1-7):C07D489/00 |
主分类号 |
A61K31/4355 |
| 代理机构 |
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代理人 |
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| 主权项 |
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