发明名称 |
Water soluble azo dyes and their synthesis and use |
摘要 |
Disclosed are water soluble azo dyes, represented by Formula I or II, and their synthesis and use. The water soluble azo dyes are synthesized by diazotizing 4-aminopyridine and coupling the resulting diazo intermediate with alkylated metanilic or orthanilic acid. To be suitable for measuring blood glucose levels, the dyes are combined with m-nitrophenyl boronic acid in an aqueous solvent. A combined ao form of the dyes with glucose shows a peak at 540 nm. At this wavelength, the absorptivity has a tendency to increase with the increasing of glucose level, which allows the measurement of blood glucose levels. wherein R has a 1-4 carbon atom length and is an alkyl, a hydroxy alkyl, a carboxyl-containing alkyl, or a sulfonyl-containing alkyl.
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申请公布号 |
US6046312(A) |
申请公布日期 |
2000.04.04 |
申请号 |
US19990436865 |
申请日期 |
1999.11.09 |
申请人 |
DONGIL TECHNOLOGY LTD. |
发明人 |
SONG, HAN-CHUL;KOH, KWANG-NAK;KANG, SHIN-WON;CHO, JIN-HO;KIM, JOOHG-HUN;LEE, SU-MI |
分类号 |
C12Q1/54;C09B29/00;C09B29/08;C09B29/09;C09B67/36;G01N31/22;G01N33/483;G01N33/52;G01N33/66;(IPC1-7):C09B29/036 |
主分类号 |
C12Q1/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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