| 摘要 |
PROBLEM TO BE SOLVED: To obtain an amide in a high yield by reacting esters with amines in the presence of a specific organic tin compound. SOLUTION: The objective compound of formula III is obtained by reacting (A) esters of formula I [R1-R3 are each H, a halogen, cyano or the like; R4 is a (substituted) alkyl or the like] (e.g. 2-methyl fuloropropanate acid) with (B) amines of the formula: R5-NH2 [R5 is H, a (substituted) 6-20C aryl or the like] (e.g. 1phenylethylamine) in the presence of (C) an organic tin compound of formula II (X, Y and Z are each a 1-10C alkoxyl, alkylthio, a halogen or the like; R6 is H or a 1-3C alkyl; R7 is a 2-4C alkylene chain), e.g. 3- aminopropyltin triisopropoxide, preferably at 20-200 deg.C. Preferably, the component C in an amount of 0.001-200 mol % to the component A and the component B in the amount of 1 equivalent to the component A are respectively used in the reaction. |
