| 摘要 |
PCT No. PCT/EP96/05729 Sec. 371 Date Sep. 30, 1998 Sec. 102(e) Date Sep. 30, 1998 PCT Filed Dec. 10, 1996 PCT Pub. No. WO97/21830 PCT Pub. Date Jun. 19, 1997The invention relates to a microbial method of in vitro transformation of a steroid into its corresponding 11 alpha -hydroxy analogue using oxygen and a microorganism selected from the Aspergillus ochraceus, Aspergillus niger, Rhizopus stolonifer, Rhizopus nigricans, Rhizopus arrhizus, and strains of Pestelotia, using as substrate a steroid having a purity of less than 97% and more than 90% at a concentration greater than 10 g/l.
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