Vanndige aerosolpreparater inneholdende aktive makromolekyler og fremgangsmate for fremstilling av tilsvarende aerosoler

摘要

Preparation of aerosols for inhalative application of biologically active macromolecules (I) (especially peptides), from an aerosol preparation which contains (I), comprises: (a) measuring a dosage amount of (I) in a measuring chamber in a nebuliser which is free of propellant gases; and (b) spraying (I) to inhalable droplets (with a particle size less than 10 mu m) within 1-2 seconds. Spraying is carried out at a pressure of 100-500 bar through a nozzle with a hydraulic diameter of 1-12 mu m. Also claimed is an aqueous aerosol composition for inhalative administration of (I), which contains 3-100 mg of (I) per ml.