发明名称 |
Alternatively targeted adenovirus |
摘要 |
The present invention provides a recombinant protein having an amino terminus of an adenoviral fiber protein and having a trimerization domain. A fiber incorporating such a protein exhibits reduced affinity for a native substrate than does a wild-type adenoviral fiber trimer. The present invention further provides an adenovirus incorporating the recombinant protein of the present invention. |
申请公布号 |
AU5819499(A) |
申请公布日期 |
2000.04.03 |
申请号 |
AU19990058194 |
申请日期 |
1999.09.10 |
申请人 |
GENVEC, INC. |
发明人 |
THOMAS J WICKHAM;IMRE KOVESDI;PETRUS W ROELVINK;JOSEPH T BRUDER |
分类号 |
C12N15/09;A61K48/00;C07K14/075;C12N7/00;C12N15/861;C12P21/02;C12R1/92 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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