发明名称 |
ANTIMESSENGER OLIGONUCLEOTIDES AND UROKINASE RECEPTOR REVERSION OF THE INVASIVE PHENOTYPE OF TRANSFORMED HUMAN FIBROBLASTS BY ANTIMESSENGER OLIGONUCLEOTIDE INHIBITION OF UROKINASE RECEPTOR GENE EXPRESSION |
摘要 |
<p>PCT No. PCT/EP95/02793 Sec. 371 Date Feb. 27, 1997 Sec. 102(e) Date Feb. 27, 1997 PCT Filed Jul. 17, 1995 PCT Pub. No. WO96/03414 PCT Pub. Date Feb. 8, 1996Antisense oligonucleotides optionally stabilized with phosphorotioate residues or analogues, or modified in the whole sugar-phosphate backbone-complementary to the human urokinase receptor messenger RNA-are able to prevent invasiveness of neoplastic cells by inhibiting the overexpression of the receptor itself, directly responsible of the invasive phenotype. Said oligomers are useful as medicaments for the treatment of primary and secondary neoplasias as well as of other pathologies wherein the urokinase receptor gene overexpression is a pathogenic event.</p> |
申请公布号 |
GR3031985(T3) |
申请公布日期 |
2000.03.31 |
申请号 |
GR19990403078T |
申请日期 |
1999.11.29 |
申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE |
发明人 |
CAPACCIOLI, SERGIO;DEL ROSSO, MARIO;FIBBI, GABRIELLA;QUATTRONE, ALESSANDRO |
分类号 |
C12N15/09;A61K9/127;A61K31/70;A61K38/00;A61K48/00;A61P35/00;C07H21/00;C07H21/04;C12N15/113;(IPC1-7):C07H21/00;C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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