| 摘要 |
<p>The invention relates to a compound with the formula where A means hydrogen, hydroxy or OY, Y being hydroxy-protection group, Ar is phenyl, optionally substituted by one or more substituents selected from halo, hydroxy, C1-C4 alkyl, C1-C4 alkoxy, CF3, C1-C4 alkoxy, C1-C4 alkyloxy and carboxy-C1-C4 alkyloxy, X - phenyl, naphthyl, biphenyl, indanyl, benzofuranyl, benzothiophenyl, 1-tetralon-6-yl, C1-C4 alkylenedioxy, pyridyl, furyl, thyenyl, and these groups are optionally substituted with up to three substituents selected from halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, NO2, CF3 and SO2CH3, and R is hydrogen, C1-C4 alkyl or a hydroxy-protected group, and to its pharmaceutically acceptable salts. These compounds and pharmaceutical compositions containing them can be applied as pain killers, antiphlogistic, diurethic, anaesthetic or neuroprotection agents or as agents for the treatment of injury or functional diseases of the intestines such as stomach aches in mammals and particularly in humans. The invention also relates to a method for the preparation of hydroxamic compounds with formula I and their intermediate compounds with formula II listed in the description. 13 claims</p> |
