BIOSENSOR CELL DEVICE AND ITS USE

摘要

A biosensor cell device comprising a test chamber cavity (42) and a piezoelectric crystal (41) coated on the surface facing the test chamber cavity (42) with an interaction partner to an analyte, the crystal (41) being connected to an oscillation unit and signal processing electronics, is disclosed. The device further comprises an inlet needle (49) for the introduction of the analyte that ends at a small distance from the end of, and inside, an inlet sleeve (50) for the introduction of buffer solution that ends in the vicinity of the active surface of the crystal (41), the inlet sleeve being connected to an inlet (47) for buffer solution, and an outlet (48) for excessive fluid. The interaction partner may be an antibody which specifically binds to the analyte (antigen) e.g. a narcotic or an explosive such as 2,4,6-trinitrotoluene (TNT). The interaction partner may be a peptide nucleic acid (PNA) oligomer and the analyte may be a polynucleotide, such as RNA, DNA and PNA polymers complementary to the PNA oligomer, or vice versa. The biosensor cell device may be used for qualitative and quantitative analysis of at least one analyte and/or its interaction partner.