METHOD FOR SOLUBILIZING PYRIDONECARBOXYLIC ACID, SOLUBILIZER THEREFOR, AQUEOUS SOLUTION PREPARATIONS CONTAINING PYRIDONECARBOXYLIC ACID AND PROCESS FOR PRODUCING THE SAME

摘要

A method for solubilizing pyridonecarboxylic acid or a pharmacologically acceptable salt thereof characterized by blending glycyrrhetinic acid or its salt with pyridonecarboxylic acid or a pharmacologically acceptable salt thereof; and aqueous solution preparations containing the thus solubilized pyridonecarboxylic acid or a pharmacologically acceptable salt thereof. By using the above solubilization method, the solubility of a pyridonecarboxylic acid compound or its salt can be elevated at around the physiological pH value thereof, which makes it possible to prepare aqueous solution preparations to be used mainly as eye drops, nasal drops, ear drops, etc.