[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVES

摘要

[1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which show adenosine A2A receptor antagonism, wherein R1 represents heteroaryl, etc.; R2 represents hydrogen, etc.; na and nb represent each an integer of 0 to 4; Q represents hydrogen, etc.; R6 represents hydrogen, etc.; R3 represents (i) hydroxy, (ii ) hydroxy(lower alkyl), (iii) lower alkoxy, or (iv) imidazo[1,2-a]pyridyl, etc .; and R4 and R5 represent each lower alkyl or aryl, or R4 and R5 form together with the adjacent carbon atom a saturated carbon ring when R3 is any of (i) to (iii); or R4 and R5 represent each hydrogen, lower alkyl or aryl, or R4 and R5 form together with the adjacent carbon atom a saturated carbon ring when R3 is (iv).