摘要 |
Described herein are compounds selective for a 5-HT1D receptor, which have general Formula (I) wherein: R1 is selected from the group consisting of a group of Formula (II), H, halo, OH, C1-6alkyl, C1-6alkoxy, C2-6alkenyl, C3- 7cycloalkoxy, C3-7cycloalkylthio, optionally substituted furanyl, optionally substituted thienyl, optionally substituted phenyloxy, and others; X is selected from the group consisting of O, S, SO, SO2, NR10 and CR11R12;-----, in ring A and ring B, represents a single or double bond provided that only one double bond is present in a ring at a time; R2 is selected from the grou p consisting of H, OH, C1-6alkyl and C1-6alkoxy; R3 is selected from the group consisting of H, OH, C1-6alkyl, C1-6alkoxy, C1-6alkylthio and optionally substituted benzyloxy; R4 is selected from the group consisting of H and C1- 4alkyl; R5 is selected from the group consisting of H, OH, C1-6alkyl and C1- 6alkoxy; R6 is selected from the group consisting of H, OH, C1-6alkoxy or null; R10 is selected from the group consisting of H, C1-6alkyl, and optionally substituted benzyl; one of R11 and R12 is selected from the group consisting of H, C1-6alkyl and optionally substituted benzyl and the other i s H; n is selected from the group consisting of an integer of from 1-3; and Z is selected from the group consisting of C and N. Also described is the use of these compounds as pharmaceuticals to treat indications where stimulation of a 5-HT1D receptor is indicated, such as migraine.
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