NEW HYDROXAMIC ACID COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To obtain a new compound useful as a metalloprotease inhibitor. SOLUTION: This compound is represented by formula I R1 is a (substituted) 1-6C alkyl, an aryl or the like; R2 is a 1-4C alkylene; R3 is X (X is a 1-6C alkyl, a 1-6C acyl or the like) or Y [Y is T-U-V (the part of V is bound to S atom and V is a 1-6C alkylene; T is an aryl or the like; U is a single bond, S, O or the like)]; R4 is a 1-6C alkyl or the like when R3 denotes Y and is a biaryl or the like when R3 denotes X or Y}, e.g. 4-(benzylsulfanyl)-2- isobutyl[(4- methoxyphenyl)sulfonyl]amino}butanehydroxamic acid. The compound represented by formula I is synthesized by using a compound represented by formula II (Ra and Rb are each a single bond for connecting CO group to S or Ra is a 1-6C alkoxy and Rb is a 1-6C alkyl) as a starting substance and then starting the process from the substitution of the primary amine functional group in the compound represented by formula II with a compound represented by the formula R1-Z (Z is an eliminable group).