| 摘要 |
PROBLEM TO BE SOLVED: To obtain the subject composition capable of avoiding cardiovascular system side effects such as QT extension and ventricular arrhythmia caused by the administration of terfenadine by adding a terfenadine carboxylate and a decongestant. SOLUTION: This medicinal composition contains (A) a terfenadine carboxylate 4-[1-hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidinyl)butyl]-α,α- dimethylbenzene acetate, 1-[p-(2-hydroxymethylprop-2-yl)-phenyl]-4-[4-(α- hydroxy-α-phenylbenzyl)piperidin-1-yl]butanol, etc.}, of the formula (Z is COOH, COOCH3, CH2OH) which is a metabolic derivative of the terfenadine, and (B) a decongestant (for example, pseudoephedrine). The component A and the component B are preferably contained in amounts of 20-200 mg and 5-150 mg, respectively, in the composition. |
