| 摘要 |
PROBLEM TO BE SOLVED: To obtain am antiallergic medicine useful for treating and preventing allergy, particularly allergic diseases I and II by incorporating, as an active ingredient, a tissue inhibitor selected from tissue inhibitors against metalloprotease(TIMPs). SOLUTION: This medicine contains, as an active ingredient, a tissue inhibitor [inhibitor which specifically inhibits the activity of matrix metalloproteases(MMPs)] selected from tissue inhibitors against metalloprotease(TIMPs). It is preferable to administer the medicine to an adult (60 kg) orally at a dose of 0.01 mg-1 g per day, or parenterally, for example, by injection at a dose of 0.001 mg-30 mg per day, or as ointment at a dose of 0.01-100 mg per each application. This medicine is useful particularly for allergy I (e.g. atopic dermatitis, bronchial asthma, and pollen disease) and allergy IV (e.g. allergic contact dermatitis).
|
