发明名称 |
BICONVEX RAPIDLY DISINTEGRATING DOSAGE FORMS |
摘要 |
Preparation of solid rapidly disintegrating dosage form (SDF) comprising a porous network of matrix forming materials (MFM) comprises: (a) overfilling a mould with a predetermined amount of aqueous composition comprising MFM so that a convex meniscus is created on top of the mould; (b) freezing; and (c) removing the solvent by subjecting the product to lyophilisation or to solid state dissolution leaving a porous network of MFM. The shape of the bottom surface of the mould is a mirror image of the shape of the frozen meniscus on the top, the mirror plane being parallel to the plane defined by the rim of the mould, yielding a dosage form shaped as a biconvex tablet, having symmetrical top and bottom surfaces. The SDF prepared as above is claimed per se. Also claimed is a metal or plastic sheet for use in the above process for preparing dosage forms shaped as biconvex tablets having symmetrical top and bottom surfaces comprising moulds arranged in a regular pattern, the shape of the bottom surface of each mould being a mirror image of the shape of a predetermined convex meniscus on the top, the mirror plane being parallel to the plane defined by the rim of the mould. |
申请公布号 |
HU9903654(A2) |
申请公布日期 |
2000.03.28 |
申请号 |
HU19990003654 |
申请日期 |
1997.06.10 |
申请人 |
Janssen Pharmaceutica N.V. |
发明人 |
LAWRENCE, JANICE;POSAGE, GARY W. |
分类号 |
A61K9/20;A61K9/44;A61K31/445;A61K31/4465;A61K31/4468 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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