| 摘要 |
PROBLEM TO BE SOLVED: To obtain a liposome formulation having excellent preserving stability and high enclosing percentage of human calcitonin by dispersing liposome containing human calcitonin in an aqueous solution having a specific pH. SOLUTION: This formulation is obtained by dispersing liposome preferably containing 5-35 mol% of lipid (e.g. phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, phosphatidic acid, cardiolipin, dicetylphosphoric acid or the like) containing human calcitonin and having a negative charge and 40-60 mol% of cholesterol in an aqueous solution having pH 5-10. In the formulation, an amount of the lipid constituting liposome is preferably used as 10-100 wt. times of human calcitonin. The objective formulation is usable as an injection formulation for subcutaneous administration or intramuscular administration, parenteral formulation for intrarectal administration, rhinenchysis administration, etc., or for peroral administration, etc. A human calcitonin concentration in the formulation is preferably 0.01-10 mg /mL.
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