发明名称 |
Polypeptides containing modified, non-natural amino acids and methods of production |
摘要 |
A method for modifying a polypeptide includes providing a polypeptide containing at least one 3,4-dehydroproline and reacting the 3,4-dehydroproline with an epoxidation agent to form a polypeptide containing 3,4-epoxyproline. The method optionally further includes reacting the polypeptide containing 3,4-epoxyproline with a reducing agent to form a polypeptide containing a hydroxyproline. Polypeptides are provided which include an amino acid having an oxirane ring. |
申请公布号 |
AU5813799(A) |
申请公布日期 |
2000.03.27 |
申请号 |
AU19990058137 |
申请日期 |
1999.09.07 |
申请人 |
UNITED STATES SURGICAL CORPORATION;DAVID N. PAOLELLA;ELLIOTT A. GRUSKIN;DOUGLAS D. BUECHTER |
发明人 |
DAVID N. PAOLELLA;ELLIOTT A. GRUSKIN;DOUGLAS D. BUECHTER |
分类号 |
C07K14/00;C07K14/78;C12N1/21;C12N15/12;C12P21/02 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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