Isolation of human pemt2 gene and methods for diagnosing and treating liver disorders

摘要

This invention relates to isolated nucleic acid molecules associated with liver disorders, in particular, nucleic acid molecules encoding human phosphatidylethanolamine N-methyltransferase-2 (PEMT2). This invention is further directed to methods for identifying individuals having or at risk of having PEMT-associated liver disorders. This invention also provides pharmaceutical compositions and methods for treating PEMT-associated liver disorders by modulating the phosphatidylethanolamine N-methyltransferase (PEMT) pathway and the phosphocholine cytiylyltransferase (CT) pathway.