an antibody which binds to a ErbB3 protein and reduces heregulin-induced formation of a ErbB2-ErbB3 protein complex

摘要

An antibody, which binds to ErbB3 protein and reduces heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell, which expresses ErbB2 and ErbB3, is claimed. The antibody, as defined above, can also have the ability to increase the binding affinity of heregulin for ErbB3 protein and/or to reduce heregulin-induced ErbB2 activation in a cell, which expresses ErbB2 and ErbB3. A cell line producing the antibody as defined above is claimed. The antibody is used in a method of determining the presence of ErbB3 proteins.