Detection and determination of the stages of coronary artery disease

摘要

A method for detecting coronary artery disease for a human patient from the general population and staging the disease, if detected; the method comprising performing the step of testing a sample from the patient for a clinically significant presence of a second marker comprising a malondialdehyde-modified atherogenic protein that is recognized by a scavenger receptor on a macrophage; and performing at least one of the following steps of either testing a sample from the patient for a clinically significant presence of a first marker comprising an oxidized atherogenic protein that is no longer recognized by a low density lipoprotein receptor but is recognized by a scavenger receptor on a macrophage; or testing a sample from the patient for a clinically significant presence of a heart protein; wherein the results from the first step and at least one of the other steps indicates whether the level of the marker in the sample from the individual is clinically significant.