Vitamin D derivatives with carbo- or heterocyclic substituents at c-25, a process for their production, intermediate products and their use for producing medicaments

摘要

Vitamin D derivatives with carbo or heterocyclic substituents at C-25 of the formula 1 where Y1 is hydrogen, OH, alkanoyloxy group with 1-12 C atoms or an aroyloxy group, Y2 is H or alkanoyl group with 1-12 C atoms or an aroyl group R1 and R2 are H or together an exocyclic methylene group, R3 and R4 are H, chlorine, fluorine, alkyl of C1-4, together a methylene group or together with quaternary carbon atom 20 a 3-7 membered, saturated or unsaturated carbocyclic ring, means a straight chain or branched carbon unit with up to 10 carbon atoms, which at any positions can have OH groups in a or b position, which in turn can be etherified or esterified, keto groups, amino groups or halogen atoms R5 and R6 are H, chlorine, fluorine, with quaternary carbon atom 25 a 3-7 membered, saturated or unsaturated carbocyclic ring, means a straight chain or branched carbon unit Z is a five or six membered carbo- or heterocyclic ring, which can be saturated, unsaturated or aromatic, and at any positions one or more alkyl chains which can be straight or branched, saturated or unsaturated and at any points can be interrupted by oxa, thia, aza groups or sulfoxide or sulfo groups. These derivatives are used for therapy of hypercalcemia (hypervitaminosis D, intoxication with calcitriol or its analogs).