| 摘要 |
A system inducing cell death at a high efficiency which has been developed by preparing nerve cells with the stable and excessive expression of APP and treating these nerve cells with an APP agonist. Also, cell death is successfully induced at a higher efficiency by preparing a nerve cell system wherein the expression of mutated APP by familial Alzheimer's disease can be induced by an external stimulus and inducing the expression of the mutated APP. Use of these systems makes it possible to screen a drug capable of controlling the cell death in sporadic and familial Alzheimer's disease. The thus obtained drug inhibiting the cell death through the activation of APP is useful as a remedy for diseases involving Alzheimer's disease in which nerve cell death participates and thus the nerve cell death should be inhibited. |
