| 摘要 |
Optionally 1-, 3- and/or 5-substituted imidazolidine-2,4-diodes (I) are prepared by reacting an aldehyde (II) with a (thio) urea compound (III) in presence of carbon monoxide and a catalytically active metal compound. Preparation of imidazolidine-2,4-diones of formula (I) involves reacting an aldehyde of formula R1CHO (II) with a urea compound of formula R3NHC(X)NHR2 (III) in presence of carbon monoxide and a catalytically active metal compound. X = O, S or Se; R1 = H; or 1-18C alkyl, alkenyl, alkynyl, aryl, 7-19C aralkyl, 3-18C heteroaryl, 4-19C heteroaralklyl, alkaryl, alkyl-(3-19C) heteroalkyl, cycloalkyl, alkylcycloalkyl or cycloalkylalkyl (all optionally substituted by one or more of heteroatoms (e.g. halo, NR1R2, PO0-3R1R2, OPO0-3R1R2, OR1, SR1, SOR1, SO2R1 or SO3R1) or groups (e.g. COOH, COOR1, CONH2 or CONHR1) and optionally having one or more CH2 groups replaced by heteroatoms such as NR1, PR1, O or S); R2, R3 = H; or 1-18C alkyl, alkenyl, alkynyl, aryl, 7-19C aralkyl, 3-18C heteroaryl, 4-19C heteroaralkyl, alkaryl, alkyl-(3-19C) heteroalkyl, cycloalkyl, alkylcycloalkyl or cycloalkylalkyl (all optionally substituted by one or more of heteroatoms (eg. halo, NR1R2, PO0-3R1R2, OPO0-3R1R2, OR1, SR1, SOR1, SO2R1 or SO3R1) and optionally having one or more CH2 groups replaced by heteroatoms such as NR1, PR1, O or S); unless specified otherwise alkyl moieties have 1-8C, alkenyl or alkynyl moieties 2-18C, aryl moieties 6-18C and cycloalkyl moieties 3-8C.
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