| 摘要 |
<p>Polypeptides that are related structurally to the protein, SPROUTY-1, can be produced recombinantly and can be used to inhibit vascularization, for example, in the context of counteracting abnormal cell proliferation or undesired angiogenesis. By the same token, a polynucleotide coding for such a polypeptide, and a complement thereof, finds application in inhibiting, for example, prostate cell proliferation, adrenal tumor growth; limiting the range of FGF levels in vivo; inhibiting an adverse effect of FGF; inhibiting bFGF and FGFR-1-mediated signaling; conteracting FGF overexpression associated with certain types of tumors controlling the growth, development, and/or differentiation of any cell responsive to FGF signaling; treating various pathologies involving hypersensitive responses to FGF; treating conditions in which there is an underexpression of sprouty-1 and treating developmental anomalies associated with disregulated FGF signaling.</p> |
