MULTIBINDING AGENTS THAT MODULATE PPAR gamma AND RXR RECEPTORS
摘要
Disclosed are novel multi-binding compounds (agents) which bind to PPAR gamma receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes and/or functions thereof. The ligands are capable of binding to either a PPAR gamma receptor or a RXR receptor, so long as at least one ligand of the multi-binding compound binds to a PPAR gamma receptor. Each of the ligands is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the PPAR gamma receptor.
申请公布号
WO9963983(A9)
申请公布日期
2000.03.23
申请号
WO1999US12669
申请日期
1999.06.07
申请人
ADVANCED MEDICINE, INC.;GRIFFIN, JOHN, H.;KARR, DANE;MORAN, EDMUND, J.