| 摘要 |
<p>A process for the preparation of S-N,N'-bis [2-hydroxy-1- (hydroxymethyl) ethyl]-5- [(2-hydroxy-1- oxopropyl) amino]-2,4,6- triiodo-1,3- benzenedicarboxamide, comprising the reaction of S-(-)-5-[[2- (acetyloxy)-1- oxopropyl] amino]-2,4,6-triiodo- 1,3-benzenedicarboxylic acid dichloride (III) with 2-amino-1,3-propanediol (serinol) without a solvent, followed by hydrolysis of the acetate group.</p> |
